Enterprise (OV-101):
- Constructed: 1974
- Status: Prototype/Test Vehicle
- Flights: Used primarily for atmospheric tests and glide tests. Never flew into space.
- Notable Events: Conducted approach and landing tests (ALT program), and later used for various ground-based tests.
Columbia (OV-102):
- Constructed: 1975
- Status: Operational Orbiter
- Flights: 28
- Maiden Flight: STS-1 (April 12–14, 1981)
- Final Flight: STS-107 (January 16–February 1, 2003)
- Notable Events: First shuttle to fly into space. Tragically lost during re-entry on STS-107.
Challenger (OV-099):
- Constructed: 1978
- Status: Operational Orbiter
- Flights: 10
- Maiden Flight: STS-6 (April 4–9, 1983)
- Final Flight: STS-51-L (January 28, 1986)
- Notable Events: Lost during launch on STS-51-L, resulting in the tragic loss of the crew.
Discovery (OV-103):
- Constructed: 1979
- Status: Operational Orbiter
- Flights: 39
- Maiden Flight: STS-41-D (August 30–September 5, 1984)
- Final Flight: STS-133 (February 24–March 9, 2011)
- Notable Events: Flew more missions than any other orbiter. Deployed the Hubble Space Telescope.
Atlantis (OV-104):
- Constructed: 1985
- Status: Operational Orbiter
- Flights: 33
- Maiden Flight: STS-51-J (October 3–7, 1985)
- Final Flight: STS-135 (July 8–21, 2011)
- Notable Events: Last shuttle to fly in space, completed the final mission of the Space Shuttle program.
Endeavour (OV-105):
- Constructed: 1987
- Status: Operational Orbiter
- Flights: 25
- Maiden Flight: STS-49 (May 7–16, 1992)
- Final Flight: STS-134 (May 16–June 1, 2011)
- Notable Events: Constructed as a replacement for Challenger. Flew the first Hubble Space Telescope servicing mission.
